FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in ChinaReport as inadecuate




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Journal of Experimental and Clinical Cancer Research

, 32:39

First Online: 10 June 2013Received: 06 February 2013Accepted: 28 May 2013DOI: 10.1186-1756-9966-32-39

Cite this article as: Chen, Y., Zhang, H., Liao, W. et al. J Exp Clin Cancer Res 2013 32: 39. doi:10.1186-1756-9966-32-39

Abstract

BackgroundPrevious evidence has shown that the FOXP3 gene was involved in the pathogenesis of several tumors; however, the correlation between single nucleotide polymorphisms SNPs in the FOXP3 gene and the susceptibility to hepatitis B-related hepatocellular carcinoma HCC remains unclear.

MethodsWe analyzed two SNPs in the FOXP3 gene, rs2280883 and rs3761549, in 392 patients with HCC, 344 patients with chronic hepatitis B CHB and 372 matched healthy controls. Genotyping was performed by MALDI-TOF Mass Spectrometry for all donors.

ResultsCompared to healthy controls, HCC patients had higher frequencies of the TT genotype 79.6% at rs2280883 and the CC genotype 77.6% at rs3761549 of the FOXP3 gene; CHB patients also had higher frequencies of the TT genotype 74.1% at rs2280883 and the CC genotype 74.6% at rs3761549. There were no significant differences in the distribution of FOXP3 genotypes between CHB donors and HCC donors. The TT genotype at rs2280883 was more frequent in patients with HCC than healthy donors P = 0.01, but no significant difference was observed in this genotype between CHB and healthy donors P = 0.479. C allele frequency at rs3761549 was higher in HCC patients than healthy donors P = 0.03, but distribution of this allele was not significantly different between CHB patients and healthy donors P = 0.11. Stratified analysis showed that the CC genotype at rs3761549 was significantly associated with a high incidence of portal vein tumor thrombus P = 0.02 and that the TT-CT genotype at rs3761549 was significantly associated with an increased rate of tumor recurrence in HCC patients P = 0.001.

ConclusionsOur results suggested that the FOXP3 gene polymorphisms at rs2280883 and rs3761549 may be associated with hepatitis B-related HCC. At rs3761549, the CC genotype and the TT-CT genotype were associated with a high incidence of portal vein tumor thrombus and tumor recurrence, respectively.

KeywordsCarcinoma Hepatocellular Hepatitis B Chronic Gene polymorphism FOXP3 AbbreviationsSNPsSingle nucleotide polymorphisms

HCCHepatocellular carcinoma

CHBChronic hepatitis B

HBVHepatitis B virus

HCVHepatitis C virus

AFPAlpha-fetoprotein

ALTAlanine aminotransferase

ASTAspartate aminotransferase

GGTγ-Glutamyl transpeptidase

TBILTotal bilirubin

MALDI-TOFMatrix-assisted laser desorption-ionization time of flight

OROdds ratio.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-9966-32-39 contains supplementary material, which is available to authorized users.

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Author: YanHui Chen - HengHui Zhang - WeiJia Liao - JinXue Zhou - GaiXia He - XingWang Xie - Ran Fei - LiLing Qin - Lai Wei - Hon

Source: https://link.springer.com/







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