Accuracy of methionine-PET in predicting the efficacy of heavy-particle therapy on primary adenoid cystic carcinomas of the head and neckReport as inadecuate




Accuracy of methionine-PET in predicting the efficacy of heavy-particle therapy on primary adenoid cystic carcinomas of the head and neck - Download this document for free, or read online. Document in PDF available to download.

Radiation Oncology

, 8:143

First Online: 13 June 2013Received: 10 December 2012Accepted: 04 June 2013DOI: 10.1186-1748-717X-8-143

Cite this article as: Toubaru, S., Yoshikawa, K., Ohashi, S. et al. Radiat Oncol 2013 8: 143. doi:10.1186-1748-717X-8-143

Abstract

BackgroundWe evaluated whether or not PET or PET-CT using L-methyl-11C-methionine MET can allow for the early prediction of local recurrence and metastasis, as well as the prognosis disease-specific survival, in patients with adenoid cystic carcinoma of the head and neck treated by carbon ion beam radiotherapy.

MethodsThis was a retrospective cohort study of sixty-seven patients who underwent a MET-PET or PET-CT study prior to and one month after the completion of carbon ion radiotherapy CIRT. The minimum follow-up period for survivors was 12 months. The MET accumulation of the tumor was evaluated using the semiquantitative tumor to normal tissue ratio TNR. A univariate analysis was conducted using the log-rank method, and the Cox model was used in a multivariate survival regression analysis.

ResultsThe average TNR prior to and following treatment was 4.8 ±1.5 and 3.0 ±1.3, respectively, showing a significant decrease following treatment. In the univariate analysis, a high TNR prior to treatment TNRpre was a significant factor for predicting the occurrence of metastasis and the disease-specific survival. A high TNR following treatment TNRpost was a significant factor for predicting the development of local recurrence. The residual ratio of TNR changes TNRratio seemed to be less useful than the TNRpre. In the multivariate analysis, the TNRpost and tumor size were the factors found to significantly influence the risk of local recurrence. The TNRpre, TNRratio and tumor size were all significant factors influencing the occurrence of metastasis. Regarding the disease-specific survival, the TNRpre and age were the only factors with a significant influence on the outcome.

ConclusionsThe TNRpre was a factor that was significantly related to the occurrence of metastasis and the disease-specific survival after CIRT for adenoid cystic carcinoma of the head and neck. The TNRpost was a factor that was significantly related to the development of local recurrence. Thus, MET-PET or PET-CT can be useful for predicting or determining the therapeutic efficacy of CIRT.

KeywordsC-11-Methionine PET Carbon ion radiotherapy Head and neck adenoid cystic carcinoma Univariate analysis Multivariate analysis Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-8-143 contains supplementary material, which is available to authorized users.

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Author: Sachiko Toubaru - Kyosan Yoshikawa - Seiya Ohashi - Katsuyuki Tanimoto - Azusa Hasegawa - Koji Kawaguchi - Tsuneo Saga - Ta

Source: https://link.springer.com/







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