11C-RPK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approachesReport as inadecuate




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European Journal of Nuclear Medicine and Molecular Imaging

, Volume 40, Issue 9, pp 1406–1419

First Online: 29 May 2013Received: 18 March 2013Accepted: 30 April 2013DOI: 10.1007-s00259-013-2447-2

Cite this article as: Su, Z., Herholz, K., Gerhard, A. et al. Eur J Nucl Med Mol Imaging 2013 40: 1406. doi:10.1007-s00259-013-2447-2

Abstract

PurposeTranslocator protein TSPO is a biomarker of neuroinflammation that can be imaged by PET using C-RPK11195. We sought to characterize the C-RPK11195 kinetics in gliomas of different histotypes and grades, and to compare two reference tissue input functions supervised cluster analysis versus cerebellar grey matter for the estimation of C-RPK11195 binding in gliomas and surrounding brain structures.

MethodsTwenty-three glioma patients and ten age-matched controls underwent structural MRI and dynamic C-RPK11195 PET scans. Tissue time–activity curves TACs were extracted from tumour regions as well as grey matter GM and white matter WM of the brains. Parametric maps of binding potential BPND were generated with the simplified reference tissue model using the two input functions, and were compared with each other. TSPO expression was assessed in tumour tissue sections by immunohistochemistry.

ResultsThree types of regional kinetics were observed in individual tumour TACs: GM-like kinetics n = 6, clearance of the tracer similar to that in cerebellar GM, WM-like kinetics n = 8, clearance of the tracer similar to that in cerebral WM and a form of mixed kinetics n = 9, intermediate rate of clearance. Such kinetic patterns differed between low-grade astrocytomas WM-like kinetics and oligodendrogliomas GM-like and mixed kinetics, but were independent of tumour grade. There was good agreement between parametric maps of BPND derived from the two input functions in all controls and 10 of 23 glioma patients. In 13 of the 23 patients, BPND values derived from the supervised cluster input were systematically smaller than those using the cerebellar input. Immunohistochemistry confirmed that TSPO expression increased with tumour grade.

ConclusionThe three types of C-RPK11195 kinetics in gliomas are determined in part by tracer delivery, and indicated that kinetic analysis is a valuable tool in the study of gliomas with the potential for in vivo discrimination between low-grade astrocytomas and oligodendrogliomas. Supervised cluster and cerebellar input functions produced consistent BPND estimates in approximately half of the gliomas investigated, but had a systematic difference in the remainder. The cerebellar input is preferred based on theoretical and practical considerations.

KeywordsTranslocator protein C-RPK11195 Kinetic analysis Reference tissue Glioma PET  Download fulltext PDF



Author: Zhangjie Su - Karl Herholz - Alexander Gerhard - Federico Roncaroli - Daniel Du Plessis - Alan Jackson - Federico Turkheim

Source: https://link.springer.com/







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