Synthesis and evaluation of methionine and folate co-decorated chitosan self-assembly polymeric micelles as a potential hydrophobic drug-delivery systemReport as inadecuate




Synthesis and evaluation of methionine and folate co-decorated chitosan self-assembly polymeric micelles as a potential hydrophobic drug-delivery system - Download this document for free, or read online. Document in PDF available to download.

Chinese Science Bulletin

, Volume 58, Issue 19, pp 2379–2386

First Online: 07 March 2013Received: 20 December 2012Accepted: 08 January 2013DOI: 10.1007-s11434-013-5733-2

Cite this article as: Chen, Y., Cao, J., Zhu, H. et al. Chin. Sci. Bull. 2013 58: 2379. doi:10.1007-s11434-013-5733-2

Abstract

In this study, an amphiphilic copolymer folate-succinyl-methionine-chitosan-octyl FSMCO was successfully synthesized step by step for self-assembling polymeric micelles. The copolymers formed micelle-like nanoparticles by their amphiphilic characteristics and structures were examined by UV-Vis absorption and Fourier transform spectroscopy. The sizes of blank and ICG derivative-loaded micelles measured by dynamic light scattering were about 170 and 140 nm, respectively, which were spherical in shape with an average zeta potential of −10 mV. Further studies on the stability showed that the micellar solutions maintain their sizes at room temperature for 1 month without distinct aggregation or dissociation. ICG derivative was much better photostable after being entrapped by the new carrier. The prepared FSMCO micelles displayed a good drug loading content 11.7%, entrapment efficiency 66.5% and sustained release rate for the model drug fluorescein. The copolymers demonstrated weeny cytotoxicity toward Bel-7402, L02 and A549 cells when incubated for 2 d. Ligands modified micelles endowed preferable cell targeting capability and beautiful cell inhibition of HCPT-FSMCO on Bel-7402 tumor cells. This kind of polymeric micelles may be a promising nanovehicle in delivering near-infrared dyes for tumors imaging and chemotherapeutic drugs for cancer therapeutics.

Keywordsfolate methionine chitosan micelles ICG derivative This article is published with open access at Springerlink.com

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Author: YuQi Chen - Jie Cao - HongYan Zhu - SiSi Cui - AQin Wang - ZhiYu Qian - YueQing Gu

Source: https://link.springer.com/







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