Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinomaReport as inadecuate




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Radiation Oncology

, 8:261

Clinical Radiation Oncology

Abstract

BackgroundVascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma NPC. This study examined if the duration after radiotherapy correlates with the progression of carotid intima-media thickness IMT and investigated its relationship with inflammatory markers.

MethodsOne hundred and five NPC patients post-radiotherapy for more than one year and 25 healthy control subjects were examined by B-mode ultrasound for IMT measurement at the far wall of the common carotid artery CCA. Surrogate markers including lipid profile, HbA1c, and high sensitive C-reactive protein hs-CRP were assessed.

ResultsThe IMT of CCA was significantly increased in NPC patients and carotid plaque was detected in 38 NPC patients 38-105, 36.2%. Significant risk factors for carotid plaques included age, duration after radiotherapy, and HbA1c levels. Age, duration after radiotherapy, hs-CRP, HbA1c, and platelet count positively correlated with IMT. The cut-off value of age and duration after radiotherapy for the presence of plaque was 52.5 years and 42.5 months, respectively. In NPC subjects, multiple linear regression analysis revealed that age, gender, duration after radiotherapy and platelet counts were independently associated with CCA IMT. After adjustments for age, gender and platelet counts, IMT increased in a linear manner with duration after radiotherapy.

ConclusionsRadiation-induced vasculopathy is a dynamic and progressive process due to late radiation effects. Extra-cranial color-coded duplex sonography can be part of routine follow-up in NPC patients aged ≥50 years at 40 months post-radiotherapy.

KeywordsAtherosclerosis Nasopharyngeal carcinoma Radiotherapy Risk factors Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-8-261 contains supplementary material, which is available to authorized users.

Chuang-Rung Chang, Teng-Yeow Tan and Cheng-Hsien Lu contributed equally to this work.

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Author: Tai Lin Huang - Hsuan Chih Hsu - Hui Chun Chen - Hsin Ching Lin - Chih Yen Chien - Fu Min Fang - Chih Cheng Huang -

Source: https://link.springer.com/







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