Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor IGF1R gene with growth-related traits in Angus cattleReport as inadecuate




Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor IGF1R gene with growth-related traits in Angus cattle - Download this document for free, or read online. Document in PDF available to download.

Journal of Applied Genetics

, Volume 54, Issue 3, pp 305–308

First Online: 19 June 2013Received: 29 August 2012Revised: 27 December 2012Accepted: 27 May 2013DOI: 10.1007-s13353-013-0155-z

Cite this article as: Szewczuk, M., Zych, S., Wójcik, J. et al. J Appl Genetics 2013 54: 305. doi:10.1007-s13353-013-0155-z

Abstract

The insulin-like growth factor 1 IGF-1 is considered to be a factor that mainly regulates growth, differentiation, and the maintenance of various function in numerous tissues through binding to a family of transmembrane tyrosine kinase receptors, signaling primarily through the insulin-like growth factor 1 receptor IGF-1R encoded by the IGF1R gene. The objectives of the present study were to estimate the allele and genotype frequencies of the IGF1R-MspI silent mutation within exon 12 and the IGF1R-TaqI within the 3′ untranslated region, 3′UTR gene polymorphisms in beef cattle and to determine associations between these polymorphisms and growth traits. In a preliminary study on 310 Angus calves, association analyses with three production traits birth weight, BWT; weaning weight adjusted to 210 days, WWT210; and average daily gain, ADG were conducted. The GG genotype of the IGF1R-e12-MspI polymorphism was significantly associated P ≤ 0.05 with a higher WWT210 +5.06 kg compared to the AG genotype. Polymorphism within the 3′UTR had no significant effect on growth traits. The effect of combined genotypes was also examined. At WWT210, calves with the GG-AA and GG-AG combinations were heavier than calves with the AG-AA and AG-AG combined genotypes P ≤ 0.05. To our knowledge, this is the first report of a polymorphism within the coding region of the Bos taurus IGF1R gene.

KeywordsBeef Genetic markers IGF1R Quantitative trait loci  Download fulltext PDF



Author: M. Szewczuk - S. Zych - J. Wójcik - E. Czerniawska-Piątkowska

Source: https://link.springer.com/







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