Labelling of a pyrazole derivative with 131I and investigation of its radiopharmaceutical potentialReport as inadecuate




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Chinese Science Bulletin

, Volume 58, Issue 24, pp 2964–2969

First Online: 18 May 2013Received: 15 January 2013Accepted: 21 February 2013DOI: 10.1007-s11434-013-5832-0

Cite this article as: Kurtdede, E., Bildirici, I., Enginar, H. et al. Chin. Sci. Bull. 2013 58: 2964. doi:10.1007-s11434-013-5832-0

Abstract

We investigated the radiolabeling efficiency, in vitro stability, and biodistribution of radioactive iodine I-labeled 4-benzoyl-1-4-carboxyphenyl-5-phenyl-1H-pyrazole-3-carboxylic acid P3CA. A quality-control study of the labeled substance I-P3CA was conducted using electrophoresis and radio thin-layer chromatography RTLC. Biodistribution studies were undertaken in 9 female albino Wistar rats. Rats were killed at various times 15, 60 and 180 min, their organs removed, and percentage of injected dose per gram ID%-g values calculated. The labeling yield of P3CA was 97.08%±0.80%. The maximum uptake of I-P3CA was seen in the lungs, stomach and spleen at 15 min. The uptake of labeled compound decreased over time in the lungs, whereas that in the stomach decreased. These data suggest that I-P3CA had high binding efficiency, high uptake in the lung, and sufficient stability to be used in diagnostic studies.

Keywordspyrazole derivative lungs I biodistribution rat This article is published with open access at Springerlink.com

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Author: Esra Kurtdede - Ishak Bildirici - Hüseyin Enginar - Ahmet Sener

Source: https://link.springer.com/







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