Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancersReport as inadecuate




Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers - Download this document for free, or read online. Document in PDF available to download.

Breast Cancer Research

, 15:R112

First Online: 25 November 2013Received: 29 January 2013Accepted: 01 November 2013DOI: 10.1186-bcr3579

Cite this article as: Masuda, H., Baggerly, K.A., Wang, Y. et al. Breast Cancer Res 2013 15: R112. doi:10.1186-bcr3579

Abstract

IntroductionBecause of its high rate of metastasis, inflammatory breast cancer IBC has a poor prognosis compared with non-inflammatory types of breast cancer non-IBC. In a recent study, Lehmann and colleagues identified seven subtypes of triple-negative breast cancer TNBC. We hypothesized that the distribution of TNBC subtypes differs between TN-IBC and TN-non-IBC. We determined the subtypes and compared clinical outcomes by subtype in TN-IBC and TN-non-IBC patients.

MethodsWe determined TNBC subtypes in a TNBC cohort from the World IBC Consortium for which IBC status was known 39 cases of TN-IBC; 49 cases of TN-non-IBC. We then determined the associations between TNBC subtypes and IBC status and compared clinical outcomes between TNBC subtypes.

ResultsWe found the seven subtypes exist in both TN-IBC and TN-non-IBC. We found no association between TNBC subtype and IBC status P = 0.47. TNBC subtype did not predict recurrence-free survival. IBC status was not a significant predictor of recurrence-free or overall survival in the TNBC cohort.

ConclusionsOur data show that, like TN-non-IBC, TN-IBC is a heterogeneous disease. Although clinical characteristics differ significantly between IBC and non-IBC, no unique IBC-specific TNBC subtypes were identified by mRNA gene-expression profiles of the tumor. Studies are needed to identify the subtle molecular or microenvironmental differences that contribute to the differing clinical behaviors between TN-IBC and TN-non-IBC.

AbbreviationsBL1Basal-like 1 subtype

BL2Basal-like 2 subtype

DMFSDistant metastasis-free survival

EGFREpidermal growth factor receptor

EMTEpithelial-mesenchymal transition

FDRsFalse discovery rates

GEGene expression

IBCInflammatory breast cancer

IMImmunomodulatory subtype

LARLuminal androgen-receptor subtype

MMesenchymal subtype

MSLMesenchymal stem-like subtype

OSOverall survival

RFSRecurrence-free survival

TNTriple-negative

TNBCTriple-negative breast cancer

TN-IBCTriple-negative inflammatory breast cancer

TN-non-IBCTriple-negative noninflammatory breast cancer

UNSUnstable subtype.

Electronic supplementary materialThe online version of this article doi:10.1186-bcr3579 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Hiroko Masuda - Keith A Baggerly - Ying Wang - Takayuki Iwamoto - Takae Brewer - Lajos Pusztai - Kazuharu Kai - Takahiro 

Source: https://link.springer.com/







Related documents