Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental DisordersReport as inadecuate




Molecular Mechanisms Underlying Activity-Dependent GABAergic Synapse Development and Plasticity and Its Implications for Neurodevelopmental Disorders - Download this document for free, or read online. Document in PDF available to download.

Neural PlasticityVolume 2011 2011, Article ID 734231, 8 pages

Review ArticleCentre de Recherche, CHU Ste-Justine, Université de Montréal, 3175, Chemin de la Côte-Ste-Catherine, Montréal, QC, Canada H3T 1C5

Received 1 March 2011; Accepted 28 April 2011

Academic Editor: Tommaso Pizzorusso

Copyright © 2011 Bidisha Chattopadhyaya. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

GABAergic interneurons are critical for the normal function and development of neural circuits, and their dysfunction is implicated in a large number of neurodevelopmental disorders. Experience and activity-dependent mechanisms play an important role in GABAergic circuit development, also recent studies involve a number of molecular players involved in the process. Emphasizing the molecular mechanisms of GABAergic synapse formation, in particular basket cell perisomatic synapses, this paper draws attention to the links between critical period plasticity, GABAergic synapse maturation, and the consequences of its dysfunction on the development of the nervous system.





Author: Bidisha Chattopadhyaya

Source: https://www.hindawi.com/



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