Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applicationsReport as inadecuate




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Chinese Science Bulletin

, Volume 58, Issue 35, pp 4342–4348

First Online: 22 June 2013Received: 15 November 2012Accepted: 20 February 2013DOI: 10.1007-s11434-013-5780-8

Cite this article as: Shah, S.R., Kasper, F.K. & Mikos, A.G. Chin. Sci. Bull. 2013 58: 4342. doi:10.1007-s11434-013-5780-8

Abstract

The emergence of orthopedic tissue engineering devices as viable clinical solutions demands that the field address significant clinical complications associated with the implantation of foreign materials in the body, especially infection. While tissue engineering has focused on the development of methods to regenerate and repair, until recently there has been a relative dearth of literature regarding the intersection of tissue engineering and infection. In particular, local delivery of antimicrobials has long been of clinical interest, but only recently has that been translated into the realm of tissue engineering. In this perspective, we briefly review major modes of local delivery for infection prevention and treatment and discuss possible strategies for preventing implant-associated infections.

Keywordstissue engineering infection antibiotic delivery antifouling agents This article is published with open access at Springerlink.com

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Author: Sarita R. Shah - F. Kurtis Kasper - Antonios G. Mikos

Source: https://link.springer.com/



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