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TheScientificWorldJOURNAL - Volume 6 2006, Pages 1619-1630

Research Article

National Evaluation Team, Israel Rett Syndrome Center Chaim Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel

Department of Physical Therapy, Academic College of Judea and Samaria, Ariel, Israel

Received 11 October 2006; Revised 13 November 2006; Accepted 13 November 2006

Academic Editor: Joav Merrick

Copyright © 2006 Lilit Zysman et al.

Abstract

Osteoporosis is the reduction of calcium density in bones, usually evident in postmenopausal females, yet the tendency for osteoporosis can also be identified at a young age, especially in patients with chronic diseases, disabilities, and on chronic anticonvalsant treatment. Individuals with Rett syndrome RS have been found to show signs of osteoporosis at a young age. This condition may cause pathological fractures, inflict pain, and seriously damage mobility. In such cases, the quality of life of the individual and her primary caretakers will be severely hampered. This article reviews the current knowledge of the phenomenon and suggests some clinical directions for the individual with RS who shows signs of osteoporosis. The article also presents novel findings from a screening test of bone strength in 35 individuals with RS at different ages using the Sunlight Omnisense 7000P ultrasound apparatus. The primary results from this investigation showed a strong and significant positive correlation between calcium intake and bone strength p < 0.0001 as well as bone density Z values p < 0.005. The occurrence and frequency of fractures were found connected with reduced bone strength in measurements of both the radius p < 0.0001 and the tibia p < 0.004 as well as with negative bone strength Z values p = 0.03. Other findings specified within the content of the article support the implementation of a comprehensive antiosteoporotic preventive management for this population.





Author: Lilit Zysman, Meir Lotan, and Bruria Ben-Zeev

Source: https://www.hindawi.com/



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