Influence of the amount of co-infused amino acids on post-therapeutic potassium levels in peptide receptor radionuclide therapyReport as inadecuate




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EJNMMI Research

, 4:46

First Online: 23 August 2014Received: 07 July 2014Accepted: 13 August 2014DOI: 10.1186-s13550-014-0046-2

Cite this article as: Lapa, C., Werner, R.A., Bluemel, C. et al. EJNMMI Res 2014 4: 46. doi:10.1186-s13550-014-0046-2

Abstract

BackgroundPeptide receptor radionuclide therapy PRRT is routinely used for advanced or metastasized neuroendocrine tumours NET. To prevent nephrotoxicity, positively charged amino acids AA are co-infused. The aim of this study was to correlate the risk for therapy-related hyperkalaemia with the total amount of AA infused.

MethodsTwenty-two patients undergoing PRRT with standard activities of Lu-DOTATATE-TOC were monitored during two following treatment cycles with co-infusion of 75 and 50 g of AA l-arginine and l-lysine, respectively. Mean serum levels of potassium and other parameters glomerular filtration rate GFR, creatinine, blood urea nitrogen BUN, phosphate, chloride, lactate dehydrogenase prior to, 4 h and 24 h after AA infusion were compared.

ResultsSelf-limiting hyperkalaemia >5.0 mmol-l resolving after 24 h occurred in 91% 20-22 of patients in both protocols. Potassium levels, BUN, creatinine, GFR, phosphate, chloride and LDH showed a similar range at 4 h after co-infusion of 75 or 50 g of AA, respectively p?>?0.05. Only GFR and creatinine levels at 24 h varied significantly between the two co-infusion protocols p?
ConclusionsHyperkalaemia is a frequent side effect of AA infusion in PRRT. Varying the dose of co-infused amino acids did not impact on the incidence and severity of hyperkalaemia.

KeywordsNET PRRT Hyperkalaemia Arginine Lysine Electronic supplementary materialThe online version of this article doi:10.1186-s13550-014-0046-2 contains supplementary material, which is available to authorized users.

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Author: Constantin Lapa - Rudolf A Werner - Christina Bluemel - Katharina Lückerath - Andreas Schirbel - Alexander Strate - Andrea

Source: https://link.springer.com/







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