P68 RNA helicase as a molecular target for cancer therapyReport as inadecuate




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Journal of Experimental and Clinical Cancer Research

, 33:64

First Online: 24 August 2014Received: 14 May 2014Accepted: 16 July 2014DOI: 10.1186-s13046-014-0064-y

Cite this article as: Dai, TY., Cao, L., Yang, ZC. et al. J Exp Clin Cancer Res 2014 33: 64. doi:10.1186-s13046-014-0064-y

Abstract

The DEAD-box family of RNA helicase is known to be required in virtually all cellular processes involving RNA, and p68 is a prototypic one of the family. Reports have indicated that in addition to ATPase and RNA helicase ability, p68 can also function as a co-activator for transcription factors such as estrogen receptor alpha, tumor suppressor p53 and beta-catenin. More than that, post-translational modification of p68 including phosphorylation, acetylation, sumoylation, and ubiquitylation can regulate the coactivation effect. Furthermore, aberrant expression of p68 in cancers highlights that p68 plays an important role for tumorgenesis and development. In this review, we briefly introduce the function and modulation of p68 in cancer cells, and put forward envisagement about future study about p68.

KeywordsRNA helicase p68 Molecular target Transcriptional co-activator AbbreviationsERαEstrogen receptor α

MyoDMyogenic differentiation antigen

Runx2Runt-related transcription factor-2

ARAndrogen receptor

TGFβTransforming growth factor β

NPMNucleophosmin

ARFAlternative reading frame

PCaProstate cancer

BPHBenign prostatic hyperplasia

SRC-1-TIF2Steroid receptor co-activator-1-transcriptional intermediary factor 2

AF-2Activation function-2

CBPCREB-binding protein

SRASteroid receptor RNA Activator

PSAprostate specific antigen

c-AblAbelson tyrosine kinase

pRbRetinoblastoma protein

E2FE2 promoterbinding factor

PDGFPlatelet derived growth factor

Mcl-1Myeloid cell leukemia-1

METMesenchymal to epithelial transition

EPSCEMT promoting Smad complexes

PKCProtein kinase C

SUMOSmall ubiquitin-related modifier

HDACHistone deacetylase

COUP-TFICOUP Transcription Factor 1

HDACIHistone deacetylase inhibitor

TRAILTumor necrosis factor-related apoptosis-inducing ligand, an anticancer agent

TCFT-cell factor

HNSCCHead and neck squamous cell carcinoma

T-ALLT cell acute lymphoblastic leukemia

SCCSquamous cell carcinoma

NBNC HCCNon-hepatitis B virus-non-hepatitis C virus-related hepatocellular carcinoma

Electronic supplementary materialThe online version of this article doi:10.1186-s13046-014-0064-y contains supplementary material, which is available to authorized users.

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Author: Ting-Yu Dai - Liu Cao - Zi-Chen Yang - Ya-Shu Li - Li Tan - Xin-Ze Ran - Chun-Meng Shi

Source: https://link.springer.com/







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