Paracrine signaling in stem cell renewal and in neoplastic tumor growthReport as inadecuate

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Science China Life Sciences

, Volume 57, Issue 6, pp 571–574

First Online: 21 May 2014Received: 15 February 2014Accepted: 02 April 2014DOI: 10.1007-s11427-014-4664-8

Cite this article as: Zhao, C. Sci. China Life Sci. 2014 57: 571. doi:10.1007-s11427-014-4664-8


Paracrine pathway activities are being increasingly recognized as instrumental regulatory mechanisms of epithelial-stromal interactions that play important roles in physiological and pathological self-renewal of stem cells and in the initiation and maintenance of neoplastic tumor development. Stromal-specific Hedgehog Hh responses and epithelial-associated Wnt pathway activities have been recently appreciated as important factors in stem cell self-renewal and carcinogenesis. Furthermore, Hh and Wnt pathways frequently crosstalk with each other to regulate the growth of epithelial cells in a context-dependent manner. Because small molecule modulators of Hh and Wnt pathway activities are readily available, emerging roles of Hh-Wnt pathway crosstalk in epithelial-stromal interactions will shed light on the development of regenerative and anticancer medicines.

KeywordsHedgehog Wnt paracrine stem cell tumor This article is published with open access at

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Author: Chen Zhao



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