The changing pattern of ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma as non-AIDS-defining cancers, by HIV status, in Tanzania over 11 years 2002-2012: a retrospective case-report studyReport as inadecuate




The changing pattern of ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma as non-AIDS-defining cancers, by HIV status, in Tanzania over 11 years 2002-2012: a retrospective case-report study - Download this document for free, or read online. Document in PDF available to download.

Infectious Agents and Cancer

, 9:42

Cancer centers in low- and middle-income countries

Abstract

BackgroundIn Tanzania, 5.1% of adults aged 15-49 are infected with HIV. While rates of HIV-related malignancies have declined globally with antiretroviral therapy ART, including Tanzania, rates of non-AIDS-defining cancers NADCs are believed to have increased. Therefore, we determined trends of three NADCs in Tanzania: ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma.

MethodsThis study was conducted at the Ocean Road Cancer Institute ORCI in Dar es Salaam. All medical records of patients diagnosed with ano-rectal cancer, squamous cell carcinoma of the eye, and Hodgkin’s lymphoma between 2002 and 2012 were reviewed regarding HIV status, cancer clinical characteristics and management. Analysis was conducted to determine trends and proportions in these three NADCs and patient characteristics.

ResultsWe identified 980 NADCs. The relative proportion of these three NADCs at ORCI out of all cancers treated increased from 2.37% in 2002 to a peak of 4.34% in 2009. The prevalence of HIV in patients diagnosed with these NADCs also increased—from 6.67% in 2002 to 20.87% in 2010—and 85% of squamous cell carcinoma of the eye cancer patients with a reported HIV status were HIV-positive.

ConclusionsThe frequency and proportions of these three NADCs in Tanzania have increased over the past 11 years, as has the prevalence of HIV positivity amongst these NADC patients. The current and possibly increasing burden of NADCs in Tanzania and other low- and middle-income countries with high HIV rates should be a focus for future cancer prevention and control and HIV therapy programs.

KeywordsNon-AIDS-defining cancer HIV Tanzania Squamous cell carcinoma of the eye Ocean Road Cancer Institute AbbreviationsNADCNon-AIDS-defining cancer

ADCAIDS-defining cancer

ORCIOcean Road Cancer Institute

SCCCSquamous cell carcinoma of the conjunctiva.

Electronic supplementary materialThe online version of this article doi:10.1186-1750-9378-9-42 contains supplementary material, which is available to authorized users.

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Author: Clare Meernik - Amr S Soliman - Twalib Ngoma - Crispin Kahesa - Julius Mwaiselage - Sofia D Merajver

Source: https://link.springer.com/



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