Transformation of Follicular Lymphoma to Double Hit B-Cell Lymphoma Causing Hypercalcemia in a 69-Year-Old Female: A Case Report and Review of the LiteratureReport as inadecuate




Transformation of Follicular Lymphoma to Double Hit B-Cell Lymphoma Causing Hypercalcemia in a 69-Year-Old Female: A Case Report and Review of the Literature - Download this document for free, or read online. Document in PDF available to download.

Case Reports in HematologyVolume 2014 2014, Article ID 619760, 8 pages

Case Report

Department of Internal Medicine, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA

Division of Pathology, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA

Received 13 March 2014; Accepted 8 July 2014; Published 4 August 2014

Academic Editor: Salah Aref

Copyright © 2014 Sakshi Kapur and Miles B. Levin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Double hit B-cell lymphomas are rare tumors that are defined by a chromosomal breakpoint affecting the MYC-8q24 locus in combination with another recurrent breakpoint, mainly a t14;18q32;q21 involving BCL2. These tumors mostly occur in adults and carry a very poor prognosis. Double hit lymphomas can occur de novo, or arise from transformation of follicular lymphoma. We report a case of a 69-year-old female with abdominal distention and progressively worsening weakness over six months. Patient presented with severe hypercalcemia and multiple intra-abdominal-pelvic masses. Histopathology results of the abdominal mass were compatible with a double hit B-cell lymphoma. However, bone marrow biopsy results showed a low grade follicular lymphoma, thus suggesting peripheral transformation of follicular lymphoma to double hit B-cell lymphoma. Patient was transferred to a tertiary care center and was started on combination chemotherapy EPOCH: doxorubicin, etoposide, vincristine, cyclophosphamide, and prednisone. Our paper highlights not only transformation of follicular lymphoma to double hit B-cell lymphoma and the challenges encountered in diagnosing and treating these aggressive tumors, but also the association of new onset-worsening hypercalcemia in such patients.





Author: Sakshi Kapur and Miles B. Levin

Source: https://www.hindawi.com/



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