Synthesis and Antimicrobial Activity of Some Novel Heterocyclic Candidates via Michael Addition Involving 4-4-Acetamidophenyl-4-oxobut-2-enoic AcidReport as inadecuate




Synthesis and Antimicrobial Activity of Some Novel Heterocyclic Candidates via Michael Addition Involving 4-4-Acetamidophenyl-4-oxobut-2-enoic Acid - Download this document for free, or read online. Document in PDF available to download.

Advances in Chemistry - Volume 2014 2014, Article ID 619749, 10 pages -

Research Article

Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

Chemistry Department, Faculty of Science, Fayoum University, Fayoum, Egypt

Received 28 May 2014; Revised 12 August 2014; Accepted 20 August 2014; Published 10 September 2014

Academic Editor: Constantinos Pistos

Copyright © 2014 Maher A. EL-Hashash et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper discusses the utility of 4-4-acetamidophenyl-4-oxobut-2-enoic acid as a key starting material for the preparation of a novel series of pyridazinones, thiazoles derivatives, and other heterocycles via interaction with nitrogen, sulfur, and carbon nucleophiles under Michael addition conditions and studies the antimicrobial activities of some of these compounds.





Author: Maher A. EL-Hashash, A. Essawy, and Ahmed Sobhy Fawzy

Source: https://www.hindawi.com/



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