68Ga-PSMA-11 PET-CT: a new technique with high potential for the radiotherapeutic management of prostate cancer patientsReport as inadecuate




68Ga-PSMA-11 PET-CT: a new technique with high potential for the radiotherapeutic management of prostate cancer patients - Download this document for free, or read online. Document in PDF available to download.

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 43, Issue 1, pp 34–41

First Online: 25 September 2015Received: 20 June 2015Accepted: 01 September 2015DOI: 10.1007-s00259-015-3188-1

Cite this article as: Sterzing, F., Kratochwil, C., Fiedler, H. et al. Eur J Nucl Med Mol Imaging 2016 43: 34. doi:10.1007-s00259-015-3188-1

Abstract

PurposeRadiotherapy is the main therapeutic approach besides surgery of localized prostate cancer. It relies on risk stratification and exact staging. This report analyses the potential of GaGlu-urea-LysAhx-HBED-CC Ga-PSMA-11, a new positron emission tomography PET tracer targeting prostate-specific membrane antigen PSMA for prostate cancer staging and individualized radiotherapy planning.

MethodsA cohort of 57 patients with prostate cancer scanned with Ga-PSMA-11 PET-CT for radiotherapy planning was retrospectively reviewed; 15 patients were at initial diagnosis and 42 patients at time of biochemical recurrence. Staging results of conventional imaging, including bone scintigraphy, CT or MRI, were compared with Ga-PSMA ligand PET-CT results and the influence on radiotherapeutic management was quantified.

ResultsGa-PSMA ligand PET-CT had a dramatic impact on radiotherapy application in the presented cohort. In 50.8 % of the cases therapy was changed.

ConclusionThe presented imaging technique of Ga-PSMA PET-CT could be a key technology for individualized radiotherapy management in prostate cancer.

KeywordsProstate cancer Ga-PSMA ligand PET-CT Radiotherapy planning Individualized radiotherapy  Download fulltext PDF



Author: Florian Sterzing - Clemens Kratochwil - Hannah Fiedler - Sonja Katayama - Gregor Habl - Klaus Kopka - Ali Afshar-Oromieh -

Source: https://link.springer.com/







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