The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogensReport as inadecuate




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Molecular and Cellular Pediatrics

, 3:14

Recent advances in pediatric gut diseases

Abstract

The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted by increasing local blood flow to overcome diminished oxygenation and avoid hypoxic stress. However, studies have shown that the physiological oxygen concentrations in several tissues are much lower than atmospheric normoxic conditions, and the oxygen supply is finely regulated in individual cell types. The gastrointestinal tract has been described to subsist in a state of physiologically low oxygen level and is thus depicted as a tissue in the state of constant low-grade inflammation. The intestinal epithelial cell layer plays a vital role in the immune response to inflammation and infections that occur within the intestinal tissue and is involved in many of the adaptation responses to hypoxic stress. This is especially relevant in the context of inflammatory disorders, such as inflammatory bowel disease IBD. Therefore, this review aims to describe the intestinal epithelial cellular response to hypoxia and the consequences for host interactions with invading gastrointestinal bacterial pathogens.

KeywordsOxygen Invasion β1 integrin Infection HIF-1α Intestine  Download fulltext PDF



Author: Nathalie E. Zeitouni - Sucheera Chotikatum - Maren von Köckritz-Blickwede - Hassan Y. Naim

Source: https://link.springer.com/



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