Subpopulation Treatment Effect Pattern Plot STEPP analysis of Ki67 assay according to histology: prognostic relevance for resected early stage ‘pure’ and ‘mixed’ lobular breast cancerReport as inadecuate




Subpopulation Treatment Effect Pattern Plot STEPP analysis of Ki67 assay according to histology: prognostic relevance for resected early stage ‘pure’ and ‘mixed’ lobular breast cancer - Download this document for free, or read online. Document in PDF available to download.

Journal of Experimental and Clinical Cancer Research

, 35:50

First Online: 22 March 2016Received: 22 January 2016Accepted: 16 March 2016DOI: 10.1186-s13046-016-0325-z

Cite this article as: Carbognin, L., Sperduti, I., Brunelli, M. et al. J Exp Clin Cancer Res 2016 35: 50. doi:10.1186-s13046-016-0325-z

Abstract

BackgroundThe aim of this analysis was to investigate the potential impact of Ki67 assay in a series of patients affected by early stage invasive lobular carcinoma ILC undergone surgery.

MethodsClinical-pathological data were correlated with disease-free and overall survival DFS-OS. The maximally selected Log-Rank statistics analysis was applied to the Ki67 continuous variable to estimate appropriate cut-offs. The Subpopulation Treatment Effect Pattern Plot STEPP analysis was performed to assess the interaction between ‘pure’ or ‘mixed’ histology ILC and Ki67.

ResultsAt a median follow-up of 67 months, 10-years DFS and OS of 405 patients were 67.8 and 79.8 %, respectively. Standardized Log-Rank statistics identified 2 optimal cut-offs 6 and 21 %; 10-years DFS and OS were 75.1, 66.5, and 30.2 % p = 0.01 and 84.3, 76.4 and 59 % p = 0.003, for patients with a Ki67 < 6 %, between 6 and 21 %, and >21 %, respectively. Ki67 and lymph-node status were independent predictor for longer DFS and OS at the multivariate analysis, with radiotherapy for DFS and age for OS. Ki67 highly replicated at the internal cross-validation analysis DFS 85 %, OS 100 %. The STEPP analysis showed that DFS rate decreases as Ki67 increases and those patients with ‘pure’ ILC performed worse than ‘mixed’ histology.

ConclusionsDespite the retrospective and exploratory nature of the study, Ki67 was able to significantly discriminate the prognosis of patients with ILC, and the effect was more pronounced for patients with ‘pure’ ILC.

KeywordsLobular Breast cancer Ki67 AbbreviationsDFSdisease free survival

ERestrogen receptor

HER2human epidermal growth factor receptor 2

IDCinvasive ductal carcinoma

ILCinvasive lobular carcinoma

OSoverall survival

PgRprogesterone receptor

PSperformance status

STEPPSubpopulation Treatment Effect Pattern Plot

Giampaolo Tortora and Emilio Bria shared last co-authorship.

Electronic supplementary materialThe online version of this article doi:10.1186-s13046-016-0325-z contains supplementary material, which is available to authorized users.

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Author: Luisa Carbognin - Isabella Sperduti - Matteo Brunelli - Lisa Marcolini - Rolando Nortilli - Sara Pilotto - Ilaria Zampiva -

Source: https://link.springer.com/



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