CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese populationReport as inadecuate




CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia are the independent risk factors for prediabetes in a Vietnamese population - Download this document for free, or read online. Document in PDF available to download.

BMC Genetics

, 16:107

Complex traits and quantitative genetics

Abstract

BackgroundPeople with prediabetes are at greater risk for heart attack, stroke, kidney disease, vision problems, nerve damage and high blood pressure, compared to those without the disease. Prediabetes is a complex disorder involving both genetic and environmental factors in its pathogenesis. This cross-sectional study aimed to investigate the independent risk factors for prediabetes, considering the contribution of genetic factors TCF7L2-rs7903146, IRS1-rs1801278, INSR-rs3745551, CDKN2A-rs10811661, and FTO-rs9939609, socio-economic status, and lifestyle factors.

ResultsAmong the candidate genes studied, the CDKN2A-rs10811661 polymorphism was found to be the most significant factor associated with prediabetes in the model unadjusted and adjusted for age, sex, obesity-related traits, systolic blood pressure, dyslipidemia, socio-economic status, and lifestyle factors. In the final model, the CDKN2A-rs10811661 polymorphism OR per T allele = 1.22, 95 % CI = 1.04–1.44, P = 0.017, systolic blood pressure OR per 10 mmHg = 1.14, 95 % CI = 1.08–1.20, P < 0.0001, waist-hip ratio OR = 1.25, 95 % CI = 1.10–1.42, P < 0.0001, dyslipidemia OR = 1.57, 95 % CI = 1.15–2.14, P = 0.004, and residence OR = 1.93, 95 % CI = 2.82–4.14, P < 0.0001 were the most significant independent predictors of prediabetes, in which the power of the adjusted prediction model was 0.646.

ConclusionsThe study suggested that the CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia were significantly associated with the increased risk of prediabetes in a Vietnamese population. The studied genetic variant had a small effect on prediabetes.

KeywordsAssociation study CDKN2A gene Prediabetes Single nucleotide polymorphism Vietnamese population AbbreviationsBMIBody mass index

CIConfidence interval

DBPDiastolic blood pressure

HCHip circumference

HDL-CHigh-density lipoprotein cholesterol

IGTImpaired glucose tolerance

IFGImpaired fasting glucose

LDL-CLow-density lipoprotein cholesterol

OGTTOral glucose tolerance test

OROdds ratio

RFLPRestriction fragment length polymorphism

SBPSystolic blood pressure

TCTotal cholesterol

T2DType 2 diabetes

TGTriglycerides

WCWaist circumference

WHRWaist–hip ratio

Electronic supplementary materialThe online version of this article doi:10.1186-s12863-015-0266-0 contains supplementary material, which is available to authorized users.

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Author: Tran Quang Binh - Nguyen Thi Trung Thu - Pham Tran Phuong - Bui Thi Nhung - Trinh Thi Hong Nhung

Source: https://link.springer.com/







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