Trends in survival of chronic lymphocytic leukemia patients in Germany and the USA in the first decade of the twenty-first centuryReport as inadecuate




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Journal of Hematology and Oncology

, 9:28

First Online: 22 March 2016Received: 01 February 2016Accepted: 11 March 2016DOI: 10.1186-s13045-016-0257-2

Cite this article as: Pulte, D., Castro, F.A., Jansen, L. et al. J Hematol Oncol 2016 9: 28. doi:10.1186-s13045-016-0257-2

Abstract

BackgroundRecent population-based studies in the United States of America USA and other countries have shown improvements in survival for patients with chronic lymphocytic leukemia CLL diagnosed in the early twenty-first century. Here, we examine the survival for patients diagnosed with CLL in Germany in 1997–2011.

MethodsData were extracted from 12 cancer registries in Germany and compared to the data from the USA. Period analysis was used to estimate 5- and 10-year relative survival RS.

ResultsFive- and 10-year RS estimates in 2009–2011 of 80.2 and 59.5 %, respectively, in Germany and 82.4 and 64.7 %, respectively, in the USA were observed. Overall, 5-year RS increased significantly in Germany and the difference compared to the survival in the USA which slightly decreased between 2003–2005 and 2009–2011. However, age-specific analyses showed persistently higher survival for all ages except for 15–44 in the USA. In general, survival decreased with age, but the age-related disparity was small for patients younger than 75. In both countries, 5-year RS was >80 % for patients less than 75 years of age but <70 % for those age 75+.

ConclusionsOverall, 5-year survival for patients with CLL is good, but 10-year survival is significantly lower, and survival was much lower for those age 75+. Major differences in survival between countries were not observed. Further research into ways to increase survival for older CLL patients are needed to reduce the persistent large age-related survival disparity.

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Author: Dianne Pulte - Felipe A. Castro - Lina Jansen - Sabine Luttmann - Bernd Holleczek - Alice Nennecke - Meike Ressing - Alexa

Source: https://link.springer.com/







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