Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndromeReport as inadecuate




Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome - Download this document for free, or read online. Document in PDF available to download.

EJNMMI Research

, 6:41

First Online: 12 May 2016Received: 01 March 2016Accepted: 28 April 2016DOI: 10.1186-s13550-016-0196-5

Cite this article as: Masuda, A., Yoshinaga, K., Naya, M. et al. EJNMMI Res 2016 6: 41. doi:10.1186-s13550-016-0196-5

Abstract

BackgroundAccelerated clearance of technetium-sestamibi MIBI has been observed after reperfusion therapy in patients with acute coronary syndrome ACS, but the mechanisms have not been fully investigated. MIBI retention may depend on mitochondrial function. The clearance rate of carbon-acetate reflects such mitochondrial functions as oxidative metabolism. The purpose of this study was to examine the mechanisms of accelerated MIBI clearance in ACS. We therefore compared it to oxidative metabolism estimated using C-acetate positron emission tomography PET.

MethodsEighteen patients mean age 69.2 ± 8.7 years, 10 males 56 % with reperfused ACS underwent MIBI single-photon emission computed tomography SPECT, echocardiography, and C-acetate PET within 3 weeks of the onset of ACS. MIBI images were obtained 30 min and 3 h after MIBI administration. Regional left ventricular LV function was evaluated by echocardiography. The measurement of oxidative metabolism was obtained through the mono-exponential fitting of the C-acetate time-activity curve kmono.

ResultsAmong 95 segments of reperfused myocardium, MIBI SPECT showed 64 normal segments group N, 14 segments with accelerated MIBI clearance group AC, and 17 segments with fixed defect group F. Group AC showed lower kmono than group N 0.041 ± 0.009 vs 0.049 ± 0.010, p = 0.02. Group F showed lower kmono than group N 0.039 ± 0.012 vs 0.049 ± 0.010, p = 0.01. However, kmono was similar in group AC and group F p = 0.99.

ConclusionsSegments with accelerated MIBI clearance showed reduced oxidative metabolism in ACS. Loss of MIBI retention may be associated with mitochondrial dysfunction.

KeywordsAcute coronary syndrome Clearance Metabolism Sestamibi AbbreviationsACSacute coronary syndrome

LADleft anterior descending artery

LCxleft circumflex artery

LVleft ventricular

MIBItechnetium-sestamibi

PCIpercutaneous coronary intervention

PETpositron emission tomography

RCAright coronary artery

SPECTsingle-photon emission computed tomography

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Author: Atsuro Masuda - Keiichiro Yoshinaga - Masanao Naya - Osamu Manabe - Satoshi Yamada - Hiroyuki Iwano - Tatsuya Okada - Chiet

Source: https://link.springer.com/







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