Small non-coding RNA biomarkers in sputum for lung cancer diagnosisReport as inadecuate

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Molecular Cancer

, 15:36

First Online: 12 May 2016Received: 18 February 2016Accepted: 04 May 2016DOI: 10.1186-s12943-016-0520-8

Cite this article as: Su, Y., Guarnera, M.A., Fang, H. et al. Mol Cancer 2016 15: 36. doi:10.1186-s12943-016-0520-8


The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers and 2 sputum small nucleolar RNA snoRNA biomarkers that can potentially be used for noninvasively diagnosing lung cancer. Here we evaluate the individual and combined applications of the two types of biomarkers in different sets of lung cancer patients and controls. Combined analysis of the miRNAs and snoRNAs has a synergistic effect with 89 % sensitivity and 89 % specificity, and may provide a useful tool for lung cancer early detection.

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Author: Yun Su - Maria A. Guarnera - HongBin Fang - Feng Jiang


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