Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and-or Blue DyeReport as inadecuate




Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and-or Blue Dye - Download this document for free, or read online. Document in PDF available to download.

Annals of Surgical Oncology

, Volume 23, Issue 7, pp 2183–2191

First Online: 29 December 2015Received: 20 August 2015DOI: 10.1245-s10434-015-5022-1

Cite this article as: Buda, A., Crivellaro, C., Elisei, F. et al. Ann Surg Oncol 2016 23: 2183. doi:10.1245-s10434-015-5022-1

Abstract

PurposeTo compare the detection rate DR and bilateral optimal mapping OM of sentinel lymph nodes SLNs in women with endometrial and cervical cancer using indocyanine green ICG versus the standard technetium-99m radiocolloid Tc radiotracer plus methylene or isosulfan blue, or blue dye alone.

MethodsFrom October 2010 to May 2015, 163 women with stage I endometrial or cervical cancer 118 endometrial and 45 cervical cancer underwent SLN mapping with Tc with blue dye, blue dye alone, or ICG. DR and bilateral OM of ICG were compared respectively with the results obtained using the standard Tc radiotracer with blue dye, or blue dye alone.

ResultsSLN mapping with Tc radiotracer with blue dye was performed on 77 of 163 women, 38 with blue dye only and 48 with ICG. The overall DR of SLN mapping was 97, 89, and 100 % for Tc with blue dye, blue dye alone, and ICG, respectively. The bilateral OM rate for ICG was 85 %—significantly higher than the 58 % obtained with Tc with blue dye p = 0.003 and the 54 % for blue dye p = 0.001. Thirty-one women 19 % had positive SLNs. Sensitivity and negative predictive value of SLN were 100 % for all techniques.

ConclusionsSLNs mapping using ICG demonstrated higher DR compared to other modalities. In addition, ICG was significantly superior to Tc with blue dye in terms of bilateral OM in women with early stage endometrial and cervical cancer. The higher number of bilateral OM may consequently reduce the overall number of complete lymphadenectomies, reducing the duration and additional costs of surgical treatment.

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Author: Alessandro Buda - Cinzia Crivellaro - Federica Elisei - Giampaolo Di Martino - Luca Guerra - Elena De Ponti - Marco Cuzzo

Source: https://link.springer.com/







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