MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progressionReport as inadecuate




MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression - Download this document for free, or read online. Document in PDF available to download.

Chinese Journal of Cancer

, 35:64

First Online: 02 July 2016Received: 14 March 2016Accepted: 22 June 2016DOI: 10.1186-s40880-016-0128-9

Cite this article as: Cheng, RF., Wang, J., Zhang, JY. et al. Chin J Cancer 2016 35: 64. doi:10.1186-s40880-016-0128-9

Abstract

BackgroundMicroRNA-506 miR-506 has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of miR-506 in pancreatic ductal adenocarcinoma PDAC remains unclear. In this study, we aimed to evaluate the phenotype of miR-506 in PDAC.

MethodsUsing miRNA in situ hybridization, we examined the expression of miR-506 in 113 PDACs and 87 paired normal pancreatic tissues. We evaluated miR-506 expression in PDAC cells, normal pancreatic ducts, and acinus-islands, and we analyzed the associations between miR-506 expression and the clinicopathologic characteristics of PDAC patients.

ResultsmiR-506 expression was higher in PDAC than in matched normal pancreatic ductal cells P < 0.001. On the other hand, the combined group of well and moderately differentiated PDACs showed higher levels of miR-506 than the poorly differentiated ones P = 0.023. Moreover, miR-506 expression was negatively associated with pathologic T category P = 0.004 and lymph node metastasis P = 0.033, suggesting that miR-506 might inhibit the progression of PDAC.

ConclusionsOur results suggest that miR-506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house-keeping, tumor-suppressing miRNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC.

KeywordsPancreatic ductal adenocarcinoma miR-506 Tumor suppressor Development Progression  Download fulltext PDF



Author: Run-Fen Cheng - Jian Wang - Jing-Yi Zhang - Lin Sun - Yan-Rui Zhao - Zhi-Qiang Qiu - Bao-Cun Sun - Yan Sun

Source: https://link.springer.com/







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