Inter-observer agreement improves with PERCIST 1.0 as opposed to qualitative evaluation in non-small cell lung cancer patients evaluated with F-18-FDG PET-CT early in the course of chemo-radiotherapyReport as inadecuate




Inter-observer agreement improves with PERCIST 1.0 as opposed to qualitative evaluation in non-small cell lung cancer patients evaluated with F-18-FDG PET-CT early in the course of chemo-radiotherapy - Download this document for free, or read online. Document in PDF available to download.

EJNMMI Research

, 6:71

First Online: 22 September 2016Received: 11 June 2016Accepted: 26 August 2016DOI: 10.1186-s13550-016-0223-6

Cite this article as: Fledelius, J., Khalil, A., Hjorthaug, K. et al. EJNMMI Res 2016 6: 71. doi:10.1186-s13550-016-0223-6

Abstract

BackgroundThe purpose of this study is to determine whether a qualitative approach or a semi-quantitative approach provides the most robust method for early response evaluation with 2′-deoxy-2′-Ffluoro-d-glucose F-18-FDG positron emission tomography combined with whole body computed tomography PET-CT in non-small cell lung cancer NSCLC.

In this study eight Nuclear Medicine consultants analyzed F-18-FDG PET-CT scans from 35 patients with locally advanced NSCLC. Scans were performed at baseline and after 2 cycles of chemotherapy. Each observer used two different methods for evaluation: 1 PET response criteria in solid tumors PERCIST 1.0 and 2 a qualitative approach. Both methods allocate patients into one of four response categories complete and partial metabolic response CMR and PMR and stable and progressive metabolic disease SMD and PMD. The inter-observer agreement was evaluated using Fleiss’ kappa for multiple raters, Cohens kappa for comparison of the two methods, and intraclass correlation coefficients ICC for comparison of lean body mass corrected standardized uptake value SUL peak measurements.

ResultsThe agreement between observers when determining the percentage change in SULpeak was -almost perfect-, with ICC = 0.959. There was a strong agreement among observers allocating patients to the different response categories with a Fleiss kappa of 0.76 0.71–0.81. In 22 of the 35 patients, complete agreement was observed with PERCIST 1.0. The agreement was lower when using the qualitative method, moderate, having a Fleiss kappa of 0.60 0.55–0.64. Complete agreement was achieved in only 10 of the 35 patients. The difference between the two methods was statistically significant p < 0.005 chi-squared.

Comparing the two methods for each individual observer showed Cohen’s kappa values ranging from 0.64 to 0.79, translating into a strong agreement between the two methods.

ConclusionsPERCIST 1.0 provides a higher overall agreement between observers than the qualitative approach in categorizing early treatment response in NSCLC patients. The inter-observer agreement is in fact strong when using PERCIST 1.0 even when the level of instruction is purposely kept to a minimum in order to mimic the everyday situation. The variability is largely owing to the subjective elements of the method.

KeywordsInter-observer agreement F-18-FDG PET-CT Lung cancer PERCIST 1.0 Response evaluation Electronic supplementary materialThe online version of this article doi:10.1186-s13550-016-0223-6 contains supplementary material, which is available to authorized users.

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Author: Joan Fledelius - Azza Khalil - Karin Hjorthaug - Jørgen Frøkiær

Source: https://link.springer.com/



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