Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer RegistryReport as inadecuate




Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry - Download this document for free, or read online. Document in PDF available to download.

Breast Cancer Research and Treatment

, Volume 160, Issue 1, pp 163–172

First Online: 19 September 2016Received: 13 September 2016Accepted: 15 September 2016DOI: 10.1007-s10549-016-3984-8

Cite this article as: Kataoka, A., Iwamoto, T., Tokunaga, E. et al. Breast Cancer Res Treat 2016 160: 163. doi:10.1007-s10549-016-3984-8

Abstract

PurposeThe aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors.

MethodsOf the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients 48.3 %, who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult YA; <35 years, middle-aged adult MA; 35–50 years, and older adult OA; >50 years patients. Five-year disease-free survival DFS and overall survival OS rates were studied.

ResultsYA patients were associated with an advanced TNM stage and aggressive characteristics e.g. human epidermal growth factor receptor 2 HER2-positive or oestrogen receptor ER-negative breast cancers compared to MA and OA patients P < 0.001. The 5-year DFS and OS rates were 79.4 % and 90.8, 88.5 and 95.0 %, and 87.8 % and 91.6 % for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS hazard ratio 1.73, 95 % confidence interval 1.42–2.10; P < 0.001 and OS hazard ratio 1.58, 95 % confidence interval 1.16–2.15; P = 0.004.

ConclusionsYoung age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients.

KeywordsBreast cancer Young women Surveillance data Prognosis Multivariable analysis Electronic supplementary materialThe online version of this article doi:10.1007-s10549-016-3984-8 contains supplementary material, which is available to authorized users.

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Author: Akemi Kataoka - Takayuki Iwamoto - Eriko Tokunaga - Ai Tomotaki - Hiraku Kumamaru - Hiroaki Miyata - Naoki Niikura - Masaak

Source: https://link.springer.com/







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