Accumulation of CD5 CD19 B lymphocytes expressing PD-1 and PD-1L in hypertrophied pharyngeal tonsilsReport as inadecuate




Accumulation of CD5 CD19 B lymphocytes expressing PD-1 and PD-1L in hypertrophied pharyngeal tonsils - Download this document for free, or read online. Document in PDF available to download.

Clinical and Experimental Medicine

, Volume 16, Issue 4, pp 503–509

First Online: 29 August 2015Received: 16 March 2015Accepted: 08 August 2015DOI: 10.1007-s10238-015-0385-y

Cite this article as: Wlasiuk, P., Niedzielski, A., Skorka, K. et al. Clin Exp Med 2016 16: 503. doi:10.1007-s10238-015-0385-y

Abstract

Programmed death-1 PD-1 is one of the most important inhibitory co-receptors expressed predominantly on activated T and B lymphocytes whose expression could be sustained by permanent antigenic stimulation accompanying chronic or recurrent tonsillitis. The expression of PD-1 and PD-1L was analyzed using flow cytometry on hypertrophied tonsils collected from 57 children. We observed high expression of PD-1 and PD-1L on certain lymphocytes subpopulations of hypertrophied tonsils; among T cells, the expression of PD-1 on protein level was higher on CD4 cells 70.3 % than on CD8 cells 35 %. Interestingly, a limited expression of PD-1 was observed on CD19 B lymphocytes 6.5 %, while CD5CD19 B cells overexpressed PD-1 52.5 %. Moreover, the expression of PD-1L was also higher on CD5CD19 B cells 16.5 % than on CD19 B cells 3.5 % and on CD4 T cells 20 % than on CD8 T cells 10 %. PD-1 and PD-1L expressions correlated only on CD5CD19 cells. In conclusion, high expression of PD-1 and PD-1L on T and B cells could represent hallmark of immune system adaptation to chronic antigenic exposition in patients with tonsillitis.

KeywordsPD-1 PD-1L CD5CD19 B cells Tonsillitis Chronic antigenic stimulation  Download fulltext PDF



Author: Paulina Wlasiuk - Artur Niedzielski - Katarzyna Skorka - Agnieszka Karczmarczyk - Joanna Zaleska - Malgorzata Zajac - Maciej

Source: https://link.springer.com/







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