n-3 LCPUFA in the reversal of hepatic steatosis: the role of ACOX and CAT-1Report as inadecuate




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The aim of this study was to investigate the roles of the Acyl co-enzyme A oxidase ACOX, carnitine acyl transferase I CAT-1 and activating protein 1 AP-1 in the reversal of hepatic steatosis with dietary change and n-3 long chain polyunsaturated fatty acid n-3 LCPUFA supplementation. Male C57BL-6J mice were given either a control diet CD or a high fat diet HFD for 12 weeks, and then continued with the CD or CD plus n-3 LCPUFA for eight weeks. After this period, body and adipose visceral tissue weight were analyzed and liver samples were taken to measure ACOX, CAT-1 and c-jun levels. The dietary change from HFD to a norm caloric diet plus n-3 LCPUFA supplementation significantly reduced liver steatosis and adipose tissue: body weight ratio, along with an increase in the hepatic ACOX and CAT-1 levels and normalization of AP-1 expression that could favor the fatty acid beta-oxidation over lipogenesis and regulate inflammation. These results provide new data on the enzymatic metabolism underlying dietary change to a norm caloric diet plus n-3 LCPUFA supplementation.Indización

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Author: Tapia, G. S.; - González Manan, D.; - D-Espessailles, A.; - Dossi, C. G.; -

Source: http://repositorio.uchile.cl/



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