Short repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellitusReport as inadecuate




Short repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellitus - Download this document for free, or read online. Document in PDF available to download.

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Objective: We evaluated the relationship between the HO1 genotype, ferritin levels and the risk of type-2 diabetes and inflammation. Research methods: Eight hundred thirty-five individuals were evaluated and classified according to their nutritional status and the presence of type-2 diabetes: 153 overweight OW; 62 obese OB; 55 type-2 diabetes mellitus DM; 202 OWDM; 239 OBDM and 124 controls C. We studied biochemical glycemia, insulin, lipid profile, liver enzyme, creatinine, hsCRP, hematological hemoglobin, free erythrocyte protoporphyrin, transferrin receptor and serum Fe and ferritin and oxidative stress SOD, GHS and TBARS parameters. We determined heme oxygenase activity and the GTn polymorphism in its gene promoter. Results: Individuals with diabetes, independent of nutritional status, showed high levels of ferritin and HO activity compared to control subjects. Allelic frequency was not different between the groups Chi2, NS however, genotypes were different Chi2, P<0.001. The SS short-short genotype was higher in all DM individuals compared to controls and MM was higher in controls. SM short-medium genotype was an independent risk factor for DM in logistic regression analysis. We observed high risk for type-2 diabetes mellitus in the presence of SM genotype and high levels of ferritin OR adjusted: 2.7; 1.9-3.6; p<0.001; compared to control group. It was also significantly related to inflammation. Conclusion: The SM genotype in HO1 gene promoter and ferritin levels were associated with higher risk for type-2 diabetes and for having a higher marker of inflammation, which is the main risk factor for the development of chronic diseases. Copyright C 2016 Elsevier GmbH. All rights reserved.Indización

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Author: Andrews, Mónica; - Leiva, Elba; - Arredondo Olguin, Miguel Armando; -

Source: http://repositorio.uchile.cl/



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