MicroRNA-125b-5p suppresses Brucella abortus intracellular survival via control of A20 expressionReport as inadecuate




MicroRNA-125b-5p suppresses Brucella abortus intracellular survival via control of A20 expression - Download this document for free, or read online. Document in PDF available to download.

BMC Microbiology

, 16:171

Microbe-host interactions and microbial pathogenicity

Abstract

BackgroundBrucella may establish chronic infection by regulating the expression of miRNAs. However, the role of miRNAs in modulating the intracellular growth of Brucella remains unclear.

ResultsIn this study, we show that Brucella. abortus infection leads to downregulation of miR-125b-5p in macrophages. We establish that miR-125b-5p targets A20, an inhibitor of the NF-kB activation. Additionally, expression of miR-125b-5p decreases A20 expression in B. abortus-infected macrophages and leads to NF-kB activation and increased production of TNFα. Furthermore, B. abortus survival is attenuated in the presence of miR-125b-5p.

ConclusionsThese results uncover a role for miR-125b-5p in the regulation of B. abortus intracellular survival via the control of A20 expression.

KeywordsBrucella abortus MiR-125 A20 Macrophage  Download fulltext PDF



Author: Ning Liu - Lin Wang - Changjiang Sun - Li Yang - Wanchun Sun - Qisheng Peng

Source: https://link.springer.com/







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