SLC14A1: a novel target for human urothelial cancerReport as inadecuate




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Clinical and Translational Oncology

pp 1–9

First Online: 06 June 2017Received: 24 March 2017Accepted: 26 May 2017DOI: 10.1007-s12094-017-1693-3

Cite this article as: Hou, R., Kong, X., Yang, B. et al. Clin Transl Oncol 2017. doi:10.1007-s12094-017-1693-3

Abstract

Urinary bladder cancer is the second commonly diagnosed genitourinary malignancy. Previously, bio-molecular alterations have been observed within certain locations such as chromosome 9, retinoblastoma gene and fibroblast growth factor receptor-3. Solute carrier family 14 member 1 SLC14A1 gene encodes the type-B urea transporter UT-B which facilitates the passive movement of urea across cell membrane, and has recently been related with human malignancies, especially for bladder cancer. Herein, we discussed the SLC14A1 gene and UT-B protein properties, aiming to elucidate the expression behavior of SLC14A1 in human bladder cancer. Furthermore, by reviewing some well-established theories regarding the carcinogenesis of bladder cancer, including several genome wide association researches, we have bridged the mechanisms of cancer development with the aberrant expression of SLC14A1. In conclusion, the altered expression of SLC14A1 gene in human urothelial cancer may implicate its significance as a novel target for research.

KeywordsUrothelium Cancer Urea transporter Gene expression  Download fulltext PDF



Author: R. Hou - X. Kong - B. Yang - Y. Xie - G. Chen

Source: https://link.springer.com/







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