Avaliação dos efeitos do subgalato de bismuto na proliferação de miofibroblastos Report as inadecuate




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Cláudia Paraguaçu Sampaio ; Karin Caroline Seidel ; Melina Branco ; Rafaela Mabile Sobreiro ;Jornal Vascular Brasileiro 2016, 15 3

Author: Rubianne Ligório de Lima

Source: http://www.redalyc.org/


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Jornal Vascular Brasileiro ISSN: 1677-5449 jvascbr.ed@gmail.com Sociedade Brasileira de Angiologia e de Cirurgia Vascular Brasil Ligório de Lima, Rubianne; Paraguaçu Sampaio, Cláudia; Seidel, Karin Caroline; Branco, Melina; Mabile Sobreiro, Rafaela Avaliação dos efeitos do subgalato de bismuto na proliferação de miofibroblastos Jornal Vascular Brasileiro, vol.
15, núm.
3, julio-septiembre, 2016, pp.
210-216 Sociedade Brasileira de Angiologia e de Cirurgia Vascular São Paulo, Brasil Available in: http:--www.redalyc.org-articulo.oa?id=245048022007 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative ORIGINAL ARTICLE Assessment of the effects of bismuth subgallate on proliferation of myofibroblasts: an experimental study in rats Avaliação dos efeitos do subgalato de bismuto na proliferação de miofibroblastos Rubianne Ligório de Lima1, Cláudia Paraguaçu Sampaio1, Karin Caroline Seidel1, Melina Branco1, Rafaela Mabile Sobreiro1 * Abstract Background: Bismuth subgallate is an insoluble heavy metal that is used for its astringent and hemostatic properties. Objective: To evaluate the effects of bismuth subgallate on the healing process by observation of myofibroblasts in the skin of rats.
Methods: A sample of 60 Wistar rats was used.
Each rat was subjected to a dorsal skin wound and allocated to one of two groups: a control group, in which 0.9% sodium chloride was administered daily, or an experimental group, in which 0.5 mg of bismuth subgallate was administered daily.
Each of these groups was further subdivided into three subsets, which were reoperated after 3, 7 and 14 days respectively for excision and collection of the skin wound specimens.
Samples were treated with hematoxylin eosin, picrosirius, and immunohistoche...





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