There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational studyReport as inadecuate




There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study - Download this document for free, or read online. Document in PDF available to download.

Reproductive Health

, 10:32

First Online: 22 June 2013Received: 02 April 2013Accepted: 11 June 2013DOI: 10.1186-1742-4755-10-32

Cite this article as: Bragatto, F.B., Barbosa, C.P., Christofolini, D.M. et al. Reprod Health 2013 10: 32. doi:10.1186-1742-4755-10-32

Abstract

BackgroundEndometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein HDL. It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease minimal-mild and moderate-severe.

Methods80 infertile women with endometriosis diagnosed by laparoscopy-laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal-mild n = 33 and moderate-severe n = 47 cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined.

ResultsThe paraoxonase activity were 191.29 ± 22.41 U-l in women with minimal-mild endometriosis and 224.85 ± 21.50 U-l in women with moderate-severe disease P = 0.274. Considering arilesterase level, the results showed 89.82 ± 4.61 U-l in women with minimal-mild endometriosis and 90.78 ± 3.43 U-l in moderate-severe disease P = 0.888.

ConclusionsEvidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal-mild or moderate-severe endometriosis.

KeywordsEndometriosis Paraoxonase Oxidative stress Infertility High-density lipoprotein  Download fulltext PDF



Author: Felipe Barca Bragatto - Caio Parente Barbosa - Denise Maria Christofolini - Carla Peluso - Aline Amaro dos Santos - Ferna

Source: https://link.springer.com/







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