Correlation between metabolic syndrome and knee osteoarthritis: data from the Korean National Health and Nutrition Examination Survey KNHANESReport as inadecuate




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BMC Public Health

, 13:603

Chronic Disease epidemiology

Abstract

BackgroundThis study was designed to investigate the correlations of knee osteoarthritis OA with metabolic syndrome MetS and MetS parameters in Korean subjects.

MethodsThis study included data from 270 subjects with knee OA and 1964 control subjects with a mean age of 54.56 SD 11.53 years taken from the Korean National Health and Nutritional Examination Survey KNHANES 2008. Multivariate logistic regression analysis was conducted to examine possible associations for knee OA with MetS and MetS parameters.

ResultsMetS was shown to be associated with an increased risk of knee OA in female subjects in unadjusted analysis OR 1.798, 95% CI 1.392, 2.322, but this significance disappeared when adjusted for confounding factors OR 1.117, 95% CI 0.805, 1.550. No significant association between MetS and knee OA was found in male subjects. Among parameters of MetS, only high waist circumference WC in female subjects was significantly associated with an increased prevalence of knee OA, even after adjusting for confounding factors, while no other significant associations were found in both male and female subjects.

ConclusionWe found that WC was associated with knee OA in female subjects, but neither MetS nor any parameters thereof were shown to be associated with knee OA in the Korean subjects of this study. Although we found no relationship between a pre-inflammatory state of MetS and knee OA, we believe further investigation of this relationship in various aspects is warranted, as MetS may also be a risk factor for complications in knee OA related procedures.

KeywordsMetabolic syndrome Knee Osteoarthritis AbbreviationsBMIBody mass index

CIConfidence interval

DBPDiastolic blood pressure

HDL-CHigh density lipoprotein cholesterol

HTNHypertension

KNHANESKorean National Health and Nutritional Examination Survey

LDL-CLow density lipoprotein cholesterol

MMonth

MetSMetabolic syndrome

MIHWAFMinistry for Health Welfare and Family Affairs

NCEPNational Cholesterol Education Program

OAOsteoarthritis

OROdds ratio

QQuartile

RARheumatoid arthritis

SDStandard deviations

SBPSystolic blood pressure

TGTriglycerides

TKATotal knee arthroplasty

WCWaist circumference.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2458-13-603 contains supplementary material, which is available to authorized users.

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Author: Chang Dong Han - Ik Hwan Yang - Woo Suk Lee - Yoo Jung Park - Kwan Kyu Park

Source: https://link.springer.com/







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