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BMC Genetics

, 18:17

Complex traits and quantitative genetics

Abstract

BackgroundMilk β-lactoglobulin β-LG content is of interest as it is associated with nutritional and manufacturing properties. It is known that milk β-LG content is strongly affected by genetic factors. In cattle, most of the genetic differences are associated with a chromosomal region on BTA11, which contains the β-LG gene. The aim of this study was to characterize this region using 777 k SNP data BovineHDbeadChip and perform a haplotype-based association study. A statistical approach was developed to build haplotypes that capture the genetic variation associated with this genomic region.

ResultsThe SNP with the most significant effect on β-lactoglobulin content was one of the 2 causal mutations responsible for the β-lactoglobulin protein variants A-B. Haplotypes based on 2 to 5 selected lead SNP were clustered in groups with different effects on β-lactoglobulin content. Four different groups were identified suggesting that β-lactoglobulin variant A and B can be further refined in A1, A2, B1 and B2.

ConclusionsThis study showed that β-lactoglobulin protein variants A-B do not explain all genetic variation associated with the tail part of BTA11 but this region contains more than one mutation with an effect on β-lactoglobulin content. These findings can be used for selection of cows with higher cheese yield, which is desirable for the dairy industry.

KeywordsDairy cow Bovine β-lactoglobulin Haplotype Association study AbbreviationsLDLinkage disequilibrium

MAFMinor allele frequency

PAEPβ-LG gene

QTLQuantitative trait loci

SNPSingle nucleotide polymorphism

β-LGbeta-lactoglobulin

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Author: Nicolas Bedere - Henk Bovenhuis

Source: https://link.springer.com/







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