Elevated CD1c Myeloid Dendritic Cell Proportions Associate With Clinical Activity and Predict Disease Reactivation in Noninfectious UveitisReport as inadecuate




Elevated CD1c Myeloid Dendritic Cell Proportions Associate With Clinical Activity and Predict Disease Reactivation in Noninfectious Uveitis - Download this document for free, or read online. Document in PDF available to download.

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PURPOSE. To test the association between elevated proportions of CD1c+ myeloid dendritic cells mDCs and disease activation-reactivation in noninfectious uveitis. METHODS. Noninfectious uveitis patients n = 89 and healthy controls n = 111 were recruited. The proportion of CD1c+ mDCs in the total dendritic cell DC population of peripheral blood was measured by flow cytometry CD1c+ mDCs gated on Lineage 1+HLADR+ DCs. Disease activity was assessed per Standardization of Uveitis Nomenclature criteria. Uveitis reactivation was ascribed to clinically quiescent patients who developed reactivation of intraocular inflammation within 6 months. RESULTS. The proportions of CD1c+ mDCs were increased in noninfectious uveitis patients, especially in active disease, compared to healthy controls. This CD1c+ mDC elevation was not associated with underlying systemic diseases, anatomic locations of uveitis, medications, or demographic factors. Longitudinal data showed that the dynamics of CD1c+ mDC levels were correlated with disease activity. The average proportion of CD1c+ mDCs in active uveitis patients was 60% so we set this as the cutoff between high and low CD1c+ mDC levels. Although 74% of quiescent patients had low proportions of CD1c+ mDCs, 26% still had high proportions. Quiescent patients with high CD1c+ mDC proportions showed increased risk of disease reactivation, compared to quiescent patients with low CD1c+ mDC proportions. CONCLUSIONS. Increased proportions of CD1c+ mDCs were associated with clinical activity, and quiescent patients with elevated CD1c+ mDCs were more likely to undergo reactivation. This suggests that CD1c+ mDC proportion may be a potential biomarker for assessing clinical activation and reactivation in noninfectious uveitis.Indización

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Author: Chen, Ping; - Urzúa Salinas, Cristhian; - Knickelbein, Jared E.; - Kim, Jane S.; - Li, Zhiyu; - Hannes, Susan; - Kuo, David; - C

Source: http://repositorio.uchile.cl/



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