Neuroprotective Effect of Ethanol Extract of Leaves of Malva parviflora against Amyloid-β- Aβ- Mediated Alzheimer’s DiseaseReport as inadecuate




Neuroprotective Effect of Ethanol Extract of Leaves of Malva parviflora against Amyloid-β- Aβ- Mediated Alzheimer’s Disease - Download this document for free, or read online. Document in PDF available to download.

International Scholarly Research Notices - Volume 2014 2014, Article ID 156976, 5 pages -

Research Article

Department of Basic Medical Sciences, Faculty of Pharmacy, Ziauddin University, Karachi 75600, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy, Ziauddin University, Karachi 75600, Pakistan

Received 30 August 2014; Revised 10 October 2014; Accepted 11 October 2014; Published 29 October 2014

Academic Editor: Mahendra P. Singh

Copyright © 2014 Muhammad Aslam and Ali Akbar Sial. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Malva parviflora L. possesses significant antioxidant potential. This study was conducted to evaluate the neuroprotective effect of ethanol extract of the leaves of Malva parviflora against amyloid-β- Aβ- mediated Alzheimer’s disease. In Morris water maze model, the extract significantly restored the defected memory of amyloid-β injected mice . The reduced levels of brain antioxidant enzymes such as glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase were also restored significantly to similar levels as seen in normal control mice . The levels of lipid peroxidase were decreased significantly in treatment group mice when compared to Alzheimer group mice . So, this study showed that ethanol extract of the leaves of Malva parviflora possesses neuroprotective activity in mice.





Author: Muhammad Aslam and Ali Akbar Sial

Source: https://www.hindawi.com/



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