In Vivo Lipid Regulation Mechanism of Polygoni Multiflori Radix in High-Fat Diet Fed RatsReport as inadecuate

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Evidence-Based Complementary and Alternative Medicine - Volume 2014 2014, Article ID 642058, 8 pages -

Research ArticleYunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China

Received 6 January 2014; Revised 12 February 2014; Accepted 12 February 2014; Published 30 April 2014

Academic Editor: Kashmira Nanji

Copyright © 2014 Pei Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mechanisms of the water extracts of Polygoni Multiflori Radix PMR and its processed products PMRP on liver lipid metabolism were observed in this paper. Aqueous extract of PMR and PMRP was given to nonalcoholic fatty liver model rats, respectively. PMR was better in reducing the contents of very low density lipoprotein VLDL than PMRP and the positive control groups. In the aspect of regulating TG, medium dose PMR reduced the activity of diacylglycerol acyltransferase DGAT to  pg-mL and promoted the expression of hepatic lipase HL to  U-mL . HL promotion ability of medium dose PMR was similar with the simvastatin positive control. Both medium and high dose of PMR showed significant alterations in TC, which were related to the downregulation effects on hydroxyl methyl-glutaryl coenzyme A reductase HMGCR and upregulation effects on cholesterol 7-alpha-hydroxylase or cytochrome P450 7A CYP7A. Quantitative relationships research indicated that the prominent effect on inhibiting the content of HMGCR , was strongly positive correlated with to the TC regulation effects. Effects of PMR on enhancing decomposition rate or reducing de novo synthesis rate of TG and TC were better than PMRP.

Author: Pei Lin, Yan Ran He, Jian Mei Lu, Na Li, Wan Gen Wang, Wen Gu, Jie Yu, and Rong Hua Zhao



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