18F-fluoro-deoxyglucose positron emission tomography-computed tomography scan findings in Rosai-Dorfman disease with IgG4-positive plasma cell infiltration mimicking breast malignancy: a case report and literature reviewReport as inadecuate




18F-fluoro-deoxyglucose positron emission tomography-computed tomography scan findings in Rosai-Dorfman disease with IgG4-positive plasma cell infiltration mimicking breast malignancy: a case report and literature review - Download this document for free, or read online. Document in PDF available to download.

Journal of Medical Case Reports

, 6:411

First Online: 30 November 2012Received: 03 June 2012Accepted: 03 September 2012DOI: 10.1186-1752-1947-6-411

Cite this article as: Fu, L., Liu, M., Song, Z. et al. J Med Case Reports 2012 6: 411. doi:10.1186-1752-1947-6-411

Abstract

IntroductionRosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare benign disorder characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation. Rosai-Dorfman disease accompanied by IgG4 plasma cell infiltration is an even rarer situation. To the best of our knowledge, no imaging report of fluoro-deoxyglucose positron emission tomography-computed tomography findings of Rosai-Dorfman disease with IgG4 plasma cell infiltration has been published, although a series of pathological research has focused on this phenomenon.

Case presentationWe reviewed the F-fluoro-deoxyglucose positron emission tomography-computed tomography scan of a 78-year-old Chinese woman with a solid mass that was found in her right breast during a health checkup. F-fluoro-deoxyglucose positron emission tomography-computed tomography showed a hypermetabolic nodule in her right breast and slightly heterogeneous increased fluoro-deoxyglucose uptake of the pulmonary nodules, which were histologically proven to be mammary Rosai-Dorfman disease with IgG4 plasma cell infiltration and pulmonary amyloidosis, respectively. A literature review was performed to gather information on this rare disease process.

ConclusionsAlthough distinguishing benign lymphoplasmacytic proliferation from malignancy may be difficult with F-fluoro-deoxyglucose positron emission tomography-computed tomography in light of the pattern and intensity of fluoro-deoxyglucose uptake, our case highlights that whole-body positron emission tomography-computed tomography imaging not only can display the extent of the disease to help complete staging but also can provide functional information about disease activity to guide biopsy.

KeywordsRosai-Dorfman disease IgG4-related sclerosing disease Amyloidosis Position emission tomography AbbreviationsF-FDGFluorine-18-fluoro-deoxyglucose

FDGFluoro-deoxyglucose

IgImmunoglobulin

IgG4-RSDIgG4-related sclerosing disease

LNLymph node

PET-CTPositron emission tomography-computed tomography

RDDRosai-Dorfman disease

SUVmaxMaximum standardized uptake value.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-1947-6-411 contains supplementary material, which is available to authorized users.

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Author: Liping Fu - Mei Liu - Zhigang Song - Baixuan Xu - Jiahe Tian

Source: https://link.springer.com/







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