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BioMed Research International - Volume 2014 2014, Article ID 627126, 6 pages -

Research Article

Department of Nephrology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China

Department of Rheumatology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China

Received 27 October 2013; Accepted 4 December 2013; Published 6 January 2014

Academic Editor: Miguel A. Gonzalez-Gay

Copyright © 2014 Ling Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Our research investigates the serum levels of three angiogenic factors in the AF family, namely, placenta growth factor PlGF, basic fibroblast growth factor bFGF, and vascular endothelial growth factor VEGF, in 54 patients with SLE SLE group and 28 healthy controls normal control through ELISA measurement. And their interrelationships were also systematically analyzed. The SLE patients were then divided into active SLE group and inactive SLE group according to the SLEDAI score. The results show that serum levels of PlGF, bFGF, and VEGF in all SLE group and active SLE group were higher than those in normal controls. Serum levels of PlGF and bFGF in inactive SLE group were higher than those in normal controls. The level of PlGF was positively correlated with VEGF in SLE patients and positive correlation is also shown in bFGF with VEGF. The levels of PlGF and VEGF in SLE patients were positively correlated with both ESR and SLEDAI score. Thus a tentative conclusion can be drawn that the serum levels of the angiogenic factors, for example, PlGF, bFGF, and VEGF, may be relevant in the pathogenesis of SLE, and the concentrations of PlGF and VEGF seem to be the markers of SLE activity.





Author: Ling Zhou, Guoyuan Lu, Lei Shen, Linfeng Wang, and Mingjun Wang

Source: https://www.hindawi.com/



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