Prevalence of gastroduodenal ulcers-erosions in patients taking low-dose aspirin with either 15 mg-day of lansoprazole or 40 mg-day of famotidine: The OITA-GF study 2Report as inadecuate




Prevalence of gastroduodenal ulcers-erosions in patients taking low-dose aspirin with either 15 mg-day of lansoprazole or 40 mg-day of famotidine: The OITA-GF study 2 - Download this document for free, or read online. Document in PDF available to download.

BMC Research Notes

, 6:116

First Online: 26 March 2013Received: 23 November 2012Accepted: 20 March 2013DOI: 10.1186-1756-0500-6-116

Cite this article as: Tamura, A., Murakami, K., Kadota, J. et al. BMC Res Notes 2013 6: 116. doi:10.1186-1756-0500-6-116

Abstract

BackgroundThe preventive effects of histamine 2 receptor antagonists vs. proton pump inhibitors on low-dose aspirin LDA-related gastroduodenal mucosal injury have not been fully investigated. We conducted a cross-sectional study to compare the prevalence of gastroduodenal ulcers or erosions in patients taking LDA with either 40 mg-day of famotidine or 15 mg-day of lansoprazole for at least three months.

MethodsOf 84 eligible patients, two taking 40 mg-day of famotidine and four taking 15 mg-day of lansoprazole refused to undergo upper gastrointestinal endoscopy. Ultimately, we performed upper gastrointestinal endoscopy in 78 patients taking either 40 mg-day of famotidine group F, n = 31 or 15 mg-day of lansoprazole group L, n = 47. The prevalence of gastroduodenal ulcers or erosions and the magnitude of gastric mucosal injury evaluated using modified Lanza scores were compared between the two groups.

ResultsNo patients in either group had gastroduodenal ulcers. Gastroduodenal erosions were more prevalent in group F than in group L 48.4% vs. 17.0%, p = 0.005. The modified Lanza scores mean ± SD were significantly higher in group F than in group L 0.9 ± 1.3 vs. 0.3 ± 0.7, p = 0.007. A multivariate logistic regression analysis showed that the use of lansoprazole was negatively associated with gastroduodenal erosions.

ConclusionsThis study suggests that 15 mg-day of lansoprazole may be more effective in preventing the development of LDA-related gastroduodenal erosions than 40 mg-day of famotidine. The preventive effects of these two regimens on the development of LDA-related gastroduodenal ulcers require further investigation.

KeywordsAspirin Gastroduodenal erosion Gastroduodenal ulcer Famotidine Lansoprazole AbbreviationsH. pyloriHelicobacter pylori

H2RAHistamine 2 receptor antagonist

LDALow-dose aspirin

PPIProton pump inhibitor

Electronic supplementary materialThe online version of this article doi:10.1186-1756-0500-6-116 contains supplementary material, which is available to authorized users.

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Author: Akira Tamura - Kazunari Murakami - Junichi Kadota - OITA-GF Study 2 Investigators

Source: https://link.springer.com/







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