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BMC Cancer

, 12:617

Genetics, genomics and epigenetics

Abstract

BackgroundThe oxidative stress mechanism is of particular interest in the pathogenesis of glioma, given the high rate of oxygen metabolism in the brain. Potential links between polymorphisms of antioxidant genes and glioma risk are currently unknown. We therefore investigated the association between polymorphisms in antioxidant genes and glioma risk.

MethodsWe examined 16 single nucleotide polymorphisms SNPs of 9 antioxidant genes GPX1, CAT, PON1, NQO1, SOD2-MnSOD, SOD3, and NOS1*2*3 in 384 glioma and 384 control cases in a Chinese hospital-based case–control study. Genotypes were determined using the OpenArray platform, which employs the chip-based Taq-Man genotyping technology. The adjusted odds ratio OR and 95% confidence interval CI were estimated using unconditional logistic regression.

ResultsUsing single-locus analysis, we identified four SNPs SOD2 V16A, SOD3 T58A, GPX1 -46 C-T, and NOS1 3’-UTR that were significantly associated with the risk of glioma development. To assess the cumulative effects, we performed a combined unfavourable genotype analysis. Compared with the reference group that exhibited no unfavourable genotypes, the medium- and high-risk groups exhibited a 1.86-fold 95% CI, 1.30-2.67 and a 4.86-fold 95% CI, 1.33-17.71 increased risk of glioma, respectively P-value for the trend < 0.001.

ConclusionsThese data suggest that genetic variations in oxidative stress genes might contribute to the aetiology of glioma.

KeywordsOxidative stress Single nucleotide polymorphism Glioma SOD2 SOD3 GPX1 NOS1 AbbreviationsSODSuperoxide dismutase

GPxGlutathione peroxidase

CATCatalase

PONParaoxonase

NQONADPH-quinone reductase

NOSNitric oxide synthase

SNPSingle nucleotide polymorphism

MMPMatrix metalloproteinases

OROdds ratio

CIConfidence interval.

Peng Zhao, Lin Zhao contributed equally to this work.

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Author: Peng Zhao - Lin Zhao - Peng Zou - Ailin Lu - Ning Liu - Wei Yan - Chunsheng Kang - Zhen Fu - Yongping You - Tao Jiang

Source: https://link.springer.com/







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