Subchronic Toxicity Study in Rats of Two New Ethyl-Carbamates with Ixodicidal ActivityReport as inadecuate




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BioMed Research International - Volume 2014 2014, Article ID 467105, 12 pages -

Research Article

Programa de Maestría y Doctorado en Ciencias de la Producción y de la Salud Animal, Universidad Nacional Autónoma de México, 04510 Ciudad Universitaria, D.F., Mexico

Laboratorio de Química Medicinal, Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico

Departamento de Ciencias Biológicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714 Cuautitlán Izcalli, Mexico

Received 21 January 2014; Accepted 13 March 2014; Published 10 April 2014

Academic Editor: Brad Upham

Copyright © 2014 María Guadalupe Prado-Ochoa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Female and male Wistar rats were used to determine the subchronic oral toxicities of two new ethyl-carbamates with ixodicidal activities ethyl-4-bromphenyl-carbamate and ethyl-4-chlorphenyl-carbamate. The evaluated carbamates were administered in the drinking water 12.5, 25 and 50 mg-kg-day for 90 days. Exposure to the evaluated carbamates did not cause mortality or clinical signs and did not affect food consumption or weight gain. However, exposure to these carbamates produced alterations in water consumption, hematocrit, percentages of reticulocytes, plasma proteins, some biochemical parameters aspartate aminotransferase, gamma-glutamyl transpeptidase, cholinesterase, and creatinine activities, thiobarbituric acid reactive substances, and the relative weight of the spleen. Histologically, slight pathological alterations were found in the liver that were consistent with the observed biochemical alterations. The nonobserved adverse effect levels NOAELs of the evaluated carbamates were 12.5 mg-kg-day for both the female and male rats. The low severity and reversibility of the majority of the observed alterations suggest that the evaluated carbamates have low subchronic toxicity.





Author: María Guadalupe Prado-Ochoa, Víctor Hugo Abrego-Reyes, Ana María Velázquez-Sánchez, Marco Antonio Muñoz-Guzmán, Patrici

Source: https://www.hindawi.com/



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