Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalisReport as inadecuate

Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis - Download this document for free, or read online. Document in PDF available to download.

Journal of Obesity - Volume 2016 2016, Article ID 4670818, 12 pages -

Research Article

Unigen Inc., 3005 1st Avenue Seattle, WA 98121, USA

Unigen Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of Korea

Received 5 May 2016; Revised 27 July 2016; Accepted 10 August 2016

Academic Editor: Aron Weller

Copyright © 2016 Mesfin Yimam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here we describe a standardized blend composed of extracts from three medicinal plants: Morus alba, Yerba mate, and Magnolia officinalis for appetite suppression and metabolic disorders management. Method. Extracts were standardized to yield a composition designated as UP601. Appetite suppression activity was tested in acute feed intake rat model. Efficacy was evaluated in C57BL-6J mouse models treated with oral doses of 1.3 g-kg-day for 7 weeks. Orlistat at 40 mg-kg-day was used as a positive control. Body compositions of mice were assessed using a dual energy X-ray absorptiometry DEXA. ELISA was done for insulin, leptin, and ghrelin level quantitation. Nonalcoholic steatohepatitis NASH scoring was conducted. Results. Marked acute hypophagia with 81.8, 75.3, 43.9, and 30.9% reductions in food intake at 2, 4, 6, and 24 hours were observed for UP601. Decreases in body weight gain 21.5% compared to the HFD at weeks 7 and 8.2% compared to baseline and calorie intake 40.5% for the first week were observed. 75.9% and 46.8% reductions in insulin and leptin, respectively, 4.2-fold increase in ghrelin level, and reductions of 18.6% in cholesterol and 59% in low-density lipoprotein were documented. A percentage body fat of 18.9%, 47.8%, 46.1%, and 30.4% was found for mice treated with normal control, HFD, Orlistat, and UP601, respectively. 59.3% less mesenteric fat pad and improved NASH scores were observed for UP601. Conclusion. UP601, a standardized botanical composition from Morus alba, Yerba mate, and Magnolia officinalis could be used as a natural alternative for appetite suppression, maintaining healthy body weight and metabolism management.




Related documents