Circulating Interferon-Gamma Levels Are Associated with Low Body Weight in Newly Diagnosed Kenyan Non-Substance Using Tuberculosis IndividualsReport as inadecuate




Circulating Interferon-Gamma Levels Are Associated with Low Body Weight in Newly Diagnosed Kenyan Non-Substance Using Tuberculosis Individuals - Download this document for free, or read online. Document in PDF available to download.

Interdisciplinary Perspectives on Infectious Diseases - Volume 2016 2016, Article ID 9415364, 9 pages -

Research Article

Department of Medical Laboratory Sciences, Masinde Muliro University of Science and Technology, P.O. Box 190, Kakamega 50100, Kenya

Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya

Received 13 August 2015; Revised 3 December 2015; Accepted 8 December 2015

Academic Editor: Thomas Nyirenda

Copyright © 2016 Nathan Shaviya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although interferon-gamma, interleukin-10, and adiponectin are key immunopathogenesis mediators of tuberculosis, their association with clinical manifestations of early stage disease is inconclusive. We determined interferon-gamma, interleukin-10, and adiponectin levels in clinically and phenotypically well-characterised non-substance using new pulmonary tuberculosis patients and controls from Kenya. Interferon-gamma levels and interferon-gamma to interleukin-10 and interferon-gamma to adiponectin ratios were elevated in tuberculosis cases. Correlation analyses in tuberculosis cases showed associations of interferon-gamma levels with body weight ; , body mass index ; , hip girth ; , and plateletcrit ; ; interferon-gamma to interleukin-10 ratio with diastolic pressure ; ; and interferon-gamma to adiponectin ratio with body weight ; , body mass index ; , and plateletcrit ; . Taken together, our results suggest mild-inflammation in early stage infection characterised by upregulation of circulating interferon-gamma production in newly infected TB patients.





Author: Nathan Shaviya, Valentine Budambula, Mark K. Webale, and Tom Were

Source: https://www.hindawi.com/



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