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E-Journal of Chemistry - Volume 7 2010, Issue 4, Pages 1507-1513



Department of Chemistry, St. Theresa’s College for Women, Eluru-534003, India

Andhra University, Visakhapatnam, India

Received 28 July 2009; Revised 31 December 2009; Accepted 25 February 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate PYRA based on the formation of oxidative coupling and precipitation, charge transfer complexation products. Method A includes the oxidative coupling reaction of PYRA with 3-methyl-2-benzathiazolinone hydrazone MBTH in presence of CeIV. The formation of oxidative coupling product with 4-amino phenazone 4-AP in presence of K3FeCN6 is incorporated in method B. Precipitation-charge transfer complex formation of the PYRA with tannic acid TA-Metol-CrVI in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods A-C are given. Regression analysis using the method of least squares was made to evaluate the slope b, intercept a and correlation coefficient r and standard error of estimation Se for each system. Determination of pyrilamine in bulk form and in pharmaceutical formulations were also incorporated.





Author: V. Annapurna, G. Jyothi, V. Nagalakshmi, and B. B. V. Sailaja

Source: https://www.hindawi.com/



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