The Effect of Biliary Decompression on Bacterial Translocation in Jaundiced RatsReport as inadecuate




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HPB Surgery - Volume 7 1993, Issue 2, Pages 99-110



Department of Surgery, Lund University, Lund, Sweden

Department of Microbiology, Lund University, Lund, Sweden

Department of Pathology, Lund University, Lund, Sweden

Department of Pharmacology, Copenhagen University, Copenhagen, Denmark

Department of Zoology, Lund University, Lund, Sweden

Department of Surgery, Lund University, Lund S-221 85, Sweden

Received 27 November 1992

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Patients with obstructive jaundice are prone to septic complications after biliary tract operations.Restoring bile flow to the intestine may help to decrease the complication rate. The present study isaimed at evaluating the effect of biliary decompression on bacterial translocation in jaundiced rats.

Sixty-six male Sprague-Dawley rats were randomly allocated to six groups subjected to common bileduct ligation CBDL and transection groups 2–6 or sham operation group 1. In groups and 2 theincidence of enteric bacterial translocation was determined 2 weeks after sham operation or CBDL. Ingroups 3–6, biliary decompression was achieved by performing a choledochoduodenostomy after 2weeks of biliary decompression. Bacterial translocation was then studied 1,2,3 and 5 weeks followingbiliary decompression.

The rate of bacterial translocation to mesenteric lymph nodes in obstructive jaundice was significantlyhigher as compared with controls, and decreased with time to nil three weeks following biliarydecompression. The incidence of bacterial translocation was closely correlated r = 0.844; p = 0.034 with serum alkaline phosphatase activity and seemed to fit with the morphological changes noted in thesmall intestine. The decrease in bacterial translocation, however, lags behind the recovery of liverfunction as measured by routine liver function tests and antipyrine clearance.

Obstructive jaundice thus promotes bacterial translocation in the rat. Biliary decompression graduallydecreases the rate of bacterial translocation.





Author: Jin Wen Ding, Roland Andersson, Vasile Soltesz, Roger Willén, Steffen Loft, Henrik E. Poulsen, Håkan Pärsson, Kjell Olsson, an

Source: https://www.hindawi.com/



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