Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI StudyReport as inadecuate




Brief Report: Anomalous Neural Deactivations and Functional Connectivity During Receptive Language in Autism Spectrum Disorder: A Functional MRI Study - Download this document for free, or read online. Document in PDF available to download.

Journal of Autism and Developmental Disorders

, Volume 45, Issue 6, pp 1905–1914

First Online: 20 December 2014DOI: 10.1007-s10803-014-2344-y

Cite this article as: Karten, A. & Hirsch, J. J Autism Dev Disord 2015 45: 1905. doi:10.1007-s10803-014-2344-y

Abstract

Neural mechanisms that underlie language disability in autism spectrum disorder ASD have been associated with reduced excitatory processes observed as positive blood oxygen level dependent BOLD responses. However, negative BOLD responses NBR associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes.

KeywordsFunctional magnetic resonance imaging fMRI Functional connectivity Psychophysiological interactions PPI Negative BOLD response NBR Neural inhibition Autism Receptive language processing This research was done at Columbia University Medical Center, Functional MRI Research Center, 710 West 168 Street, New York, NY, 10032.

Download fulltext PDF



Author: Ariel Karten - Joy Hirsch

Source: https://link.springer.com/







Related documents